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Document ID (ISN)60589
CIS number 93-1204
ISSN - Serial title 1775-8785 - Archives des maladies professionnelles
Year 1992
Convention or series no.
Author(s) Guindo Nignan M., Garnier R., Telolahy P., Auger J., Ditcharles D., Dossier E., Klein E., Nguyen-Auvier D., Renault B.
Title Urinary concentrations of inorganic arsenic, methylarsonic acid and dimethylarsinic acid in workers engaged in the production of gallium arsenide semi-conductors
Original title Excrétion urinaire d'arsenic minéral, d'acide méthylarsonique et d'acide diméthylarsinique lors de la fabrication de micro-composants sur substrat d'arséniure de gallium [in French]
Bibliographic information 1992, Vol.53, No.5, p.375-381. Illus. 33 ref.
Abstract The determination of urinary concentrations of inorganic arsenic methylarsonic acid (M.A.A.) and dimethylarsinic acid (D.M.A.) through direct hydride generation from urine is an easy, inexpensive and reliable method for the biological monitoring of workers exposed to inorganic arsenic. This method was used for the biological monitoring of 79 workers engaged in the manufacturing of gallium arsenide semi-conductors in 7 different plants. 238 urine samples were obtained. The results presented are in agreement with those of two similar studies of smaller groups of gallium arsenide-exposed workers. Increases in urinary inorganic arsenic, methylarsonic acid and dimethylarsinic acid concentrations were rare and always small. The mean total urinary arsenic concentration was low (<20µg/g creatinine); more than 90% of all measurements were consistent with dietary-only arsenic absorption; no-one showed inorganic arsenic absorption corresponding to an 8h TWA of 100µg/m3 or more (i.e. half the French TLV).
Descriptors (primary) arsenic acid; gallium arsenide; methylarsonic acid; exposure tests; determination in urine; inorganic acids
Descriptors (secondary) semiconductor devices; exposure; sampling and analysis; epidemiologic study
Document type D - Periodical articles
Country / State or ProvinceFrance
Subject(s) Toxic and dangerous substances
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Biological monitoring
Inorganic acids
Arsenic and compounds
Inorganic substances