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Document ID (ISN)60536
CIS number 93-1274
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 1993
Convention or series no.
Author(s) Bas Bueno de Mesquita H., Doornbos G., van der Kuip D.A.M., Kogevinas M., Winkelmann R.
Title Occupational exposure to phenoxy herbicides and chlorophenols and cancer mortality in the Netherlands
Bibliographic information Feb. 1993, Vol.23, No.2, p.289-300. 20 ref.
Abstract A cohort of 2,310 workers from two plants who manufacture and prepare chlorophenoxy herbicides in the Netherlands was followed during the periods 1955-1985 and 1965-1986, respectively. In 1963, there was an industrial accident in one factory with concomitant release of dioxin into the environment. Mortality data on 963 exposed and 1,111 nonexposed men were evaluated by external and internal comparison. Compared with national rates, total mortality (94 deaths, SMR = 101; 95% confidence interval [CI], 82-124) and cancer mortality (31 deaths, SMR = 107; 95% CI, 73-152) for exposed workers were not significantly increased. A statistically insignificant increase was observed for non-Hodgkin's lymphoma. There was no increase in either total mortality in cancer mortality among the 139 workers probably exposed to dioxins during the 2,4,5-trichlorophenol production accident. Compared with nonexposed workers, exposed workers did not exhibit a higher total mortality. Mortality due to all cancers and respiratory cancer was not significantly elevated. These findings suggest that the increases in cancer mortality among workers exposed to phenoxy herbicides and chlorophenols may be attributable to chance.
Descriptors (primary) agricultural chemicals; herbicides; chlorophenols; dioxins; mortality; phenoxyacetic acids
Descriptors (secondary) Netherlands; IARC; lymphoma; comparative study; 2,3,5-trichlorophenol; neoplasms; lung cancer
Document type D - Periodical articles
Country / State or ProvinceNetherlands; WHO
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Agricultural chemicals
Phenols and phenolic compounds
Heterocyclic compounds