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CISDOC database

Document ID (ISN)60457
CIS number 93-1258
ISSN - Serial title 0091-6765 - Environmental Health Perspectives
Year 1991
Convention or series no.
Author(s) Dearfield K.L., Quest J.A., Whiting R.J., Stack H.F., Waters M.D.
Title Characteristics of the U.S. EPA's Office of Pesticide Programs' Toxicity Information Databases
Bibliographic information Dec. 1991, Vol.96, p.53-56. 8 ref.
Abstract Under the U.S. Environmental Protection Agency's Office of Pesticide Programs (OPP), toxicity testing data are submitted and entered into various databases which contain the information used for hazard evaluations as part of the OPP review of pesticides. The studies are listed in an archival database to catalogue and allow retrieval of the study for review. Reviews of toxicity studies are then placed in a separate database that can be retrieved to support a regulatory position. Toxicity information for health effects other than cancer and gene mutations from chronic exposure is reviewed through a reference dose (RfD) approach, and these decisions and supporting data are entered into an RfD database. Carcinogenicity data are peer reviewed and the decisions are entered into a database to show the regulatory decision with supporting data. The mutagenicity data are reviewed and acceptable data are entered into the Genetic Activity Profile system to catalogue and display the information.
Descriptors (primary) USA; pesticides; safety and health documentation; toxicity evaluation; computerized data bases; hazard evaluation
Descriptors (secondary) toxic effects; carcinogens; dose-response relationship; animal experiments; in vitro experiments; teratogens
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Safety and health information
Agricultural chemicals
Risk evaluation