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Document ID (ISN)60135
CIS number 93-833
ISSN - Serial title 0007-1072 - British Journal of Industrial Medicine
Year 1991
Convention or series no.
Author(s) Coggon D., Pannett B., Winter P.
Title Mortality and incidence of cancer at four factories making phenoxy herbicides
Bibliographic information Mar. 1991, Vol.48, No.3, p.173-178. 25 ref.
Abstract To assess the possible carcinogenicity of phenoxy herbicides and related chlorophenols and dioxins, the International Agency for Research on Cancer is coordinating an international collaborative study of workers exposed to these compounds in their production or use. Four British cohorts of chemical manufacturers which have been recruited to the survey are described. They comprise a total of 2239 men employed during 1963-85. Their mortality was compared with that in the national population. Two deaths were from non-Hodgkin's lymphoma with 0.87 expected. Both deaths occurred more than 10 years after first exposure to phenoxy compounds. One further non-Hodgkin's lymphoma was registered in a living subject with probable exposure to phenoxy compounds. A non-significant excess of lung cancer (19 deaths observed, 14.2 expected) is probably attributable to chance or a confounding effect of smoking. In one cohort only there was increased mortality from circulatory disease (34 deaths observed, 20.4 expected). A nested case-control study did not point to any occupational cause for this excess, but further evaluation will be needed during continued follow up.
Descriptors (primary) herbicides; phenoxyacetic acids; pesticide production; carcinogenic effects; mortality
Descriptors (secondary) IARC; Hodgkin's disease; lung cancer; comparative study; frequency rates; neoplasms; hazard evaluation
Document type D - Periodical articles
Country / State or ProvinceUnited Kingdom
Subject(s) Chemicals, plastics and rubber
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Chemical industry
Agricultural chemicals