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CISDOC database
| Document ID (ISN) | 59996 |
| CIS number |
93-599 |
| ISSN - Serial title |
0271-3586 - American Journal of Industrial Medicine |
| Year |
1992 |
| Convention or series no. |
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| Author(s) |
Egeland G.M., Bloom T.F., Schnorr T.M., Hornung R.W., Suruda A.J., Wille K.K. |
| Title |
Fluorocarbon 113 exposure and cardiac dysrhythmias among aerospace workers |
| Bibliographic information |
Dec. 1992, Vol.22, No.6, p.851-857. 15 ref. |
| Abstract |
The cardiotoxic effects of 1,1,2-trichloro-1,2,2-trifluoroethane (fluorocarbon 113 or FC113) exposures among healthy workers cleaning rocket and ground support equipment for the National Aeronautic and Space Administration (NASA) programmes were investigated. Exposure and ambulatory electrocardiographic (ECG) monitoring data were evaluated on 16 workers, each of whom was examined on exposed and non-exposed workdays. Overall, no subject differences in the rate of ventricular and supraventricular premature beats (number per 1,000 heart beats), fluctuations in the length of the P-R interval, or heart rate were found. The levels of FC113 exposures below the Occupational Safety and Health Administration (OSHA) 8h time-weighted-average (TWA) standard of 1,000ppm did not induce cardiac dysrhythmias or subtle changes in cardiac activity. However, because fluorocarbons may sensitise the heart to epinephrine, this study's negative findings based on sedentary and fairly health workers may not be generalised in relation to other populations of workers who are not as healthy or engaged in more physically demanding work. |
| Descriptors (primary) |
threshold limit values; 1,1,2-trichloro-1,2,2-trifluoroethane; short-term exposure; heart diseases; aircraft repair and maintenance; arrhythmia |
| Descriptors (secondary) |
electrocardiographic changes; exposure tests; pulse rate; toxic substances |
| Document type |
D - Periodical articles |
| Country / State or Province | USA |
| Subject(s) |
Transport and communications
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| Broad subject area(s) |
Chemical safety
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| Browse category(ies) |
Aerospace manufacturing and maintenance industry
Occupational exposure limits
Cardiovascular diseases
Halogenated hydrocarbons
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