|Document ID (ISN)||59772|
|Convention or series no.
||ECETOC Technical Report No.52
||Styrene toxicology investigations on the potential for carcinogenicity
||European Centre for Ecotoxicology and Toxicology of Chemicals, 4 Avenue E. Van Nieuwenhuyse, 1160 Bruxelles, Belgium, Nov. 1992. 61p. ca. 180 ref.
||New toxicokinetic data on styrene and the metabolic occurrence of styrene oxide are presented along with information on macromolecular binding in vivo. Based on experimental data, a physiologically-based pharmacokinetic model for styrene and styrene oxide was developed, validated and used to calculate the body burden of these compounds for man in relation to animals. From results of these studies and DNA binding studies, it is concluded that the carcinogenic potential of styrene, if one exists at all, must be so low that occupational or environmental exposure to styrene is unlikely to present any genotoxic or carcinogenic hazard for man.
||mutagenic effects; styrene; toxicology; carcinogenicity tests; toxicity evaluation; carcinogenic effects; styrene oxide
||literature survey; mathematical models; animal experiments; metabolic process
||E - Books, reports, proceedings
|Country / State or Province||Belgium|
||Toxic and dangerous substances
|Broad subject area(s)
||Antifertility and prenatal effects
Genetic factors in reaction to exposures