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CISDOC database

Document ID (ISN)59772
CIS number 93-605
Year 1992
Convention or series no. ECETOC Technical Report No.52
Title Styrene toxicology investigations on the potential for carcinogenicity
Bibliographic information European Centre for Ecotoxicology and Toxicology of Chemicals, 4 Avenue E. Van Nieuwenhuyse, 1160 Bruxelles, Belgium, Nov. 1992. 61p. ca. 180 ref.
Abstract New toxicokinetic data on styrene and the metabolic occurrence of styrene oxide are presented along with information on macromolecular binding in vivo. Based on experimental data, a physiologically-based pharmacokinetic model for styrene and styrene oxide was developed, validated and used to calculate the body burden of these compounds for man in relation to animals. From results of these studies and DNA binding studies, it is concluded that the carcinogenic potential of styrene, if one exists at all, must be so low that occupational or environmental exposure to styrene is unlikely to present any genotoxic or carcinogenic hazard for man.
Descriptors (primary) mutagenic effects; styrene; toxicology; carcinogenicity tests; toxicity evaluation; carcinogenic effects; styrene oxide
Descriptors (secondary) literature survey; mathematical models; animal experiments; metabolic process
Document type E - Books, reports, proceedings
Country / State or ProvinceBelgium
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Antifertility and prenatal effects
Aromatic hydrocarbons
Ethylene oxide
Genetic factors in reaction to exposures