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Document ID (ISN)59478
CIS number 93-254
ISSN - Serial title 0355-3140 - Scandinavian Journal of Work, Environment and Health
Year 1992
Convention or series no.
Author(s) Prescott E., Netterstrĝm B., Faber J., Hegedüs L., Suadicani P., Christensen J.M.
Title Effect of occupational exposure to cobalt blue dyes on the thyroid volume and function of female plate painters
Bibliographic information Apr. 1992, Vol.18, No.2, p.101-104. 17 ref.
Abstract The effect of industrial cobalt exposure on thyroid volume and function was determined for 61 female plate painters exposed to cobalt blue dyes in two Danish porcelain factories and 48 unexposed referents. Thyroid volume was determined by ultrasonography. The cobalt blue dyes were used in one of two forms, cobalt aluminate (insoluble) and cobalt-zinc silicate (semisoluble). Only the subjects exposed to semisoluble cobalt had a significantly increased urinary cobalt content (1.17µg.mmol-1 versus 0.13µg.mmol-1, p<0.0001). These subjects also had increased levels of serum thyroxine (T4) and free thyroxine (FT4I) (p=0.0001 and 0.0029, respectively) unaltered serum thyroid stimulating hormone (TSH), and marginally reduced 3,5,3'-triiodothyronine (T3), whereas thyroid volume tended to be lower (p=0.14). The group exposed to insoluble cobalt did not differ significantly in any thyroid-related parameters. No correlation between urinary cobalt and FT4I or thyroid volume was found. The study demonstrates an effect of cobalt on thyroid hormone metabolism.
Descriptors (primary) cobalt; dyes; pottery industry; painting; women; thyroid disorders
Descriptors (secondary) thyroid gland; thyroid function; comparative study; determination in urine; ultrasonic examinations; exposure tests
Document type D - Periodical articles
Country / State or ProvinceDenmark
Subject(s) Materials, glass and ceramics
Broad subject area(s) Chemical safety
Browse category(ies) Endocrine diseases
Glass, pottery and related materials
Surface treatment
Inorganic substances