| Document ID (ISN) | 59454 |
| CIS number |
93-162 |
| ISSN - Serial title |
0355-3140 - Scandinavian Journal of Work, Environment and Health |
| Year |
1992 |
| Convention or series no. |
|
| Author(s) |
Bonde J.P.E., Olsen J.H., Hansen K.S. |
| Title |
Adverse pregnancy outcome and childhood malignancy with reference to paternal welding exposure |
| Bibliographic information |
June 1992, Vol.18, No.3, p.169-177. Illus. 31 ref. |
| Abstract |
This study examines reproductive end points in a Danish cohort of 10,059 metalworkers who fathered 3,569 children in 1973 through 1986. Occupational histories were gathered by postal questionnaires. Information on pregnancy outcomes and offspring was obtained by record linkage to medical registers. The occurrence of reduced birthweight, preterm delivery, infant mortality, and congenital malformation was not increased among children at risk from paternal welding exposure in comparison with children not at risk. The overall incidence of childhood malignancies among 23,264 children born in 1968 through 1986 with a total of 259,113 person-years of follow-up was equal to national rates (relative risk 0.97, 95% confidence interval 0.63-1.42). However, pregnancies preceding a birth at risk from paternal exposure to stainless steel welding were more often terminated by spontaneous abortion (odds ratio 1.9, 95% confidence interval 1.1-3.2). This finding needs cautious interpretation and the effects of exposure to welding on spermatogenesis should be further investigated. |
| Descriptors (primary) |
children; welding fumes; spermatogenic disturbances; welding and cutting; carcinogenic effects; steelworks; genetic effects |
| Descriptors (secondary) |
stainless steel; abortion; neoplasms; long-term study; questionnaire survey |
| Document type |
D - Periodical articles |
| Country / State or Province | Denmark |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
Industries and occupations
|
| Browse category(ies) |
Iron and steel industry
Welding and cutting
Genetic factors in reaction to exposures
Antifertility and prenatal effects
Diseases of the reproductive system
|
