| Document ID (ISN) | 59453 |
| CIS number |
93-223 |
| ISSN - Serial title |
0355-3140 - Scandinavian Journal of Work, Environment and Health |
| Year |
1992 |
| Convention or series no. |
|
| Author(s) |
Brown D.P. |
| Title |
Mortality of workers employed at organochlorine pesticide manufacturing plants - An update |
| Bibliographic information |
June 1992, Vol.18, No.3, p.155-161. 15 ref. |
| Abstract |
A previous mortality study among four organochlorine pesticide manufacturers was updated through 1987. The organochlorine pesticides included chlordane; heptachlor and endrin; aldrin, dieldrin and endrin; and dichlorodiphenyltrichloroethane. The mortality for all causes and all malignant neoplasms at each of the plants was lower than expected. There was a statistically significant increase in liver and biliary tract cancer among workers at plant 3 (five observed, standardised mortality ratio 393, 95% confidence interval 1.27-9.20). These results are somewhat consistent with experimental animal findings showing benign and malignant tumours of the liver after exposure to aldrin and dieldrin. However, the deaths were due to a mixture of intra- and extra-hepatic tumours (biliary tract and gall-bladder), and the dose-response analysis was limited because of the small number of deaths and lack of exposure data. Additional study of this group should include continued follow-up of the total cohort and a case-referent analysis of the deaths from liver and biliary tract cancer. |
| Descriptors (primary) |
DDT; chlorinated condensed hydrocarbons; aldrin; dieldrin; endrin; pesticide production; heptachlor; chlorinated organic compounds; mortality; pesticides; liver cancer; chlordane |
| Descriptors (secondary) |
benign tumours; comparative study; long-term study; cancer |
| Document type |
D - Periodical articles |
| Country / State or Province | USA |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Agricultural chemicals
Halogenated hydrocarbons
Chemical industry
|
