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CISDOC database

Document ID (ISN)59375
CIS number 93-213
ISSN - Serial title 0003-0805 - American Review of Respiratory Disease
Year 1992
Convention or series no.
Author(s) Vandenplas O., Malo J.L., Cartier A., Perreault G., Cloutier Y.
Title Closed-circuit methodology for inhalation challenge tests with isocyanates
Bibliographic information Mar. 1992, Vol.145, No.3, p.582-587. Illus. 30 ref.
Abstract A closed-circuit apparatus for generating isocyanates in a gaseous form was developed to help in the diagnosis of isocyanate-induced occupational asthma. Twenty subjects suspected of having isocyanate-induced asthma were tested using both the older, small challenge room method and the newer method in a randomised sequential way. Isocyanate concentrations were more stable with the closed-circuit apparatus than with the challenge room method. The percentage of the total exposure time during which concentrations were above 20ppb was reduced from 11.3 to 4.5%. The two methods yielded the same number of positive and negative responses, except for one subject who did not have a positive reaction when tested with the challenge room method. The pattern and magnitude of asthmatic reactions were similar for both methods. However, the duration of exposure was shorter with the challenge room method than with the closed-circuit method.
Descriptors (primary) isocyanates; asthma; inhalation tests; closed circuit breathing apparatus; allergy tests; diagnosis
Descriptors (secondary) description of technique; permissible levels
Document type D - Periodical articles
Country / State or ProvinceCanada
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Isocyanates
Cyano compounds
Respiratory protection