Document ID (ISN) | 59375 |
CIS number |
93-213 |
ISSN - Serial title |
0003-0805 - American Review of Respiratory Disease |
Year |
1992 |
Convention or series no. |
|
Author(s) |
Vandenplas O., Malo J.L., Cartier A., Perreault G., Cloutier Y. |
Title |
Closed-circuit methodology for inhalation challenge tests with isocyanates |
Bibliographic information |
Mar. 1992, Vol.145, No.3, p.582-587. Illus. 30 ref. |
Abstract |
A closed-circuit apparatus for generating isocyanates in a gaseous form was developed to help in the diagnosis of isocyanate-induced occupational asthma. Twenty subjects suspected of having isocyanate-induced asthma were tested using both the older, small challenge room method and the newer method in a randomised sequential way. Isocyanate concentrations were more stable with the closed-circuit apparatus than with the challenge room method. The percentage of the total exposure time during which concentrations were above 20ppb was reduced from 11.3 to 4.5%. The two methods yielded the same number of positive and negative responses, except for one subject who did not have a positive reaction when tested with the challenge room method. The pattern and magnitude of asthmatic reactions were similar for both methods. However, the duration of exposure was shorter with the challenge room method than with the closed-circuit method. |
Descriptors (primary) |
isocyanates; asthma; inhalation tests; closed circuit breathing apparatus; allergy tests; diagnosis |
Descriptors (secondary) |
description of technique; permissible levels |
Document type |
D - Periodical articles |
Country / State or Province | Canada |
Subject(s) |
Toxic and dangerous substances
|
Broad subject area(s) |
Chemical safety
|
Browse category(ies) |
Diseases of the respiratory system (except for pneumoconiosis & similar) Isocyanates Cyano compounds Respiratory protection
|