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CISDOC database

Document ID (ISN)59358
CIS number 93-146
ISSN - Serial title 0096-1736 - Journal of Occupational Medicine
Year 1991
Convention or series no.
Author(s) Robins T.G., Weinstein R.J., Demers R.Y.
Title Lymphocytopenia, T-lymphocyte subsets, and colorectal polyps in automotive pattern and model makers
Bibliographic information Apr. 1991, Vol.33, No.4, p.510-515. 26 ref.
Abstract The association of total lymphocyte, CD4 (T-helper cell), CD8 (T-suppressor cell), CD2 (total T-cell), and CD16 (natural killer cell) counts with biopsy-proved colorectal polyp status was investigated in 70 pattern makers. In logistic regression analyses after adjusting for age or trade years, pack-years smoked, and material worked with most frequently, a history of any type of polyp was significantly associated with total lymphocyte count (odds ratio of 2.01 for a 500 cell/cc decrease, p=0.03), and somewhat associated with decreased CD4 and CD2 counts (p values of 0.06 and 0.07, respectively). In linear regression models adjusted for age, pattern and model makers had (regardless of polyp status) significantly lower CD4, CD8, CD2, and CD16 counts than did laboratory reference controls (p value less than 0.01 for each comparison). The findings appear consistent with a sequence of carcinogenesis initiated by workplace exposure of pattern and model makers that depresses immune surveillance and therefore promotes the development of colorectal polyps as a precursor of carcinoma.
Descriptors (primary) blood count; lymphocytes; rectal cancer; autoimmunization; neoplasms; pattern and model making; motor vehicle industry; blood cytology; gastrointestinal cancer
Descriptors (secondary) USA; statistical evaluation; questionnaire survey; Michigan
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Metal production and metalworking
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Motor vehicle manufacturing industry
Gastrointestinal diseases