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Document ID (ISN)59166
CIS number 92-2010
ISSN - Serial title 0339-6517 - Documents pour le médecin du travail
Year 1991
Convention or series no. DMT 48 TC 39 Fiche médico-technique No.39
Author(s) Pillière F., Falcy M.
Title Exposure to genotoxic chemical products: Biological markers used in the monitoring of workers
Original title Exposition aux produits chimiques génotoxiques - Marqueurs biologiques pour la surveillance des salariés [in French]
Bibliographic information 4th Quarter 1991, No.48, p.329-336. Illus. 40 ref.
Abstract This information note surveys the scientific literature on genotoxic products, i.e. those that are liable to induce cancers or genetic mutations. The advantages and disadvantages of current methods used for the monitoring of workers exposed to such products are discussed. These methods are: 1. Detection of mutagenic activity in biological fluids (the Ames test). 2. Tests that detect cytogenetic changes (chromosomal aberrations, micronuclei, sister-chromatic exchanges) in human cells. 3. Protein and DNA adducts. 4. Unscheduled DNA synthesis (UDS). All these tests are subject to very sensitive interpretation, and there are actually few laboratories able to carry them out. As far as choice is concerned, it makes more sense to use a short-time test (sister-chromatic exchanges, adducts) when monitoring recent exposure, and a long-term test (chromosomal aberrations) when monitoring ancient or cumulative exposure.
Descriptors (primary) toxic substances; biological hazards; genetic effects; exposure evaluation
Descriptors (secondary) literature survey; DNA; mutagenicity tests; chromosome changes; biological effects; data sheet; exposure tests; biochemical tests; cytogenetic studies; analysis of chromosome aberrations; description of technique; determination in biological matter
Document type F - Information notes, codes of practice, standards
Country / State or ProvinceFrance
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Antifertility and prenatal effects
Biological hazards
Genetic factors in reaction to exposures
Exposure evaluation