|Document ID (ISN)||59166|
|ISSN - Serial title
||0339-6517 - Documents pour le médecin du travail
|Convention or series no.
||DMT 48 TC 39
Fiche médico-technique No.39
||Pillière F., Falcy M.
||Exposure to genotoxic chemical products: Biological markers used in the monitoring of workers
||Exposition aux produits chimiques génotoxiques - Marqueurs biologiques pour la surveillance des salariés [in French]|
||4th Quarter 1991, No.48, p.329-336. Illus. 40 ref.
||This information note surveys the scientific literature on genotoxic products, i.e. those that are liable to induce cancers or genetic mutations. The advantages and disadvantages of current methods used for the monitoring of workers exposed to such products are discussed. These methods are: 1. Detection of mutagenic activity in biological fluids (the Ames test). 2. Tests that detect cytogenetic changes (chromosomal aberrations, micronuclei, sister-chromatic exchanges) in human cells. 3. Protein and DNA adducts. 4. Unscheduled DNA synthesis (UDS). All these tests are subject to very sensitive interpretation, and there are actually few laboratories able to carry them out. As far as choice is concerned, it makes more sense to use a short-time test (sister-chromatic exchanges, adducts) when monitoring recent exposure, and a long-term test (chromosomal aberrations) when monitoring ancient or cumulative exposure.
||toxic substances; biological hazards; genetic effects; exposure evaluation
||literature survey; DNA; mutagenicity tests; chromosome changes; biological effects; data sheet; exposure tests; biochemical tests; cytogenetic studies; analysis of chromosome aberrations; description of technique; determination in biological matter
||F - Information notes, codes of practice, standards
|Country / State or Province||France|
||Toxic and dangerous substances
|Broad subject area(s)
||Antifertility and prenatal effects
Genetic factors in reaction to exposures