| Document ID (ISN) | 59082 |
| CIS number |
92-1889 |
| ISSN - Serial title |
0003-0805 - American Review of Respiratory Disease |
| Year |
1992 |
| Convention or series no. |
|
| Author(s) |
Saetta M., Maestrelli P., Di Stefano A., De Marzo N., Milani G.F., Pivirotto F., Mapp C.E., Fabbri L.M. |
| Title |
Effect of cessation of exposure to toluene diisocyanate (TDI) on bronchial mucosa of subjects with TDI-induced asthma |
| Bibliographic information |
Jan. 1992, Vol.145, No.1, p.169-174. Illus. 18 ref. |
| Abstract |
The effect of cessation of exposure to toluene diisocyanate (TDI) was studied in six patients with TDI-induced asthma. At diagnosis, asthmatic subjects had thickened reticular basement membrane and increased numbers of mononuclear cells and eosinophils in the lamina propria when compared with control subjects. Electron microscopy showed degranulation of eosinophils and mast cells in asthmatics. Six months after cessation of exposure, the thickness of the reticular basement membrane was significantly reduced compared with that at diagnosis, and it decreased to values similar to those of control biopsies. Inflammatory cell numbers in bronchial mucosa of asthmatic subjects did not change significantly six months after removal from exposure, and degranulation of eosinophils and mast cells was still present. At the end of the study, airway hyperresponsiveness to methacholine and/or sensitivity to TDI persisted in most of the asthmatic patients despite the cessation of exposure and the disappearance of asthmatic symptoms. |
| Descriptors (primary) |
tolylene diisocyanate; exposure; asthma |
| Descriptors (secondary) |
inflammations; biopsy; lung biopsy; hypersensitivity; inhalation tests |
| Document type |
D - Periodical articles |
| Country / State or Province | Italy |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
Occupational medicine, epidemiology
|
| Browse category(ies) |
Cyano compounds
Diseases of the respiratory system (except for pneumoconiosis & similar)
Isocyanates
|
