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CISDOC database

Document ID (ISN)59075
CIS number 92-1906
ISSN - Serial title 0300-5771 - International Journal of Epidemiology
Year 1991
Convention or series no.
Author(s) Michaels D., Zoloth S.R., Stern F.B.
Title Does low-level lead exposure increase risk of death? - A mortality study of newspaper printers
Bibliographic information Dec. 1991, Vol.20, No.4, p.978-983. 40 ref.
Abstract This study examined the mortality of newspaper typesetters (N=1,261) followed from 1961 to 1984, in order to investigate the effects of low-level lead exposure. Standardised Mortality Ratios (SMRs) were calculated using New York City comparison rates. The all-cause SMR was 0.74, significantly different from 1.00. Other statistically significant deficits were deaths from arteriosclerotic heart disease (SMR=0.63) and non-malignant diseases of the respiratory system (SMR=0.57) and digestive system (SMR=0.65). These can be attributed to the comparison bias known as the healthy worker effect. The SMR for cerebrovascular disease (CVD) was 1.35, on the edge of statistical significance. For those printers employed for 30 years or more, the CVD SMR was 1.68. No significant excesses were seen for any other cause of death in any exposure stratum. These findings suggest the possibility that lead exposure at levels below the current US permissible exposure limit (PEL) may also be associated with CVD mortality.
Descriptors (primary) printing and duplicating; composition; mortality; lead
Descriptors (secondary) healthy worker effect; USA; long-term exposure; circulatory disorders of the brain; epidemiologic study; New York
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Paper-making and printing
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Inorganic substances
Printing, photography and photocopying industry
Lead and compounds