| Document ID (ISN) | 59060 |
| CIS number |
92-1886 |
| ISSN - Serial title |
0091-6765 - Environmental Health Perspectives |
| Year |
1991 |
| Convention or series no. |
|
| Author(s) |
Goodman G., Wilson R. |
| Title |
Predicting the carcinogenicity of chemicals in humans from rodent bioassay data |
| Bibliographic information |
Aug. 1991, Vol.94, p.195-218. Illus. 163 ref. |
| Abstract |
It is argued that it is always more useful to know a chemical's carcinogenic potency (with confidence limits) than to be able to say only qualitatively that it has been found to be a carcinogen. Extrapolation of high-dose bioassay results to low doses does not take into consideration the possibility of a threshold dose, below which the carcinogenic potency is much lower or even zero. Threshold dose-response phenomena may be far more relevant to the aetiology of cancer in the rodent bioassays than was earlier realised; if so, there is an even greater need for establishing dose-dependent potency estimates. The paper emphasises interspecies comparison of high-dose potencies. The qualitative and quantitative comparison of carcinogenicities between mice and rats and between rodents and humans is reviewed. It is concluded that there is a good qualitative (yes/no) correlation for both the rat/mouse and the rodent/human comparison. The upper limits on potencies in humans are consistent with rodent potencies for those chemicals for which human exposure data are available. |
| Descriptors (primary) |
carcinogens; rodents; carcinogenic effects; animal experiments; extrapolation animal man; experimental pathology |
| Descriptors (secondary) |
legal aspects; limitation of exposure; neoplasms; prediction; prediction formulae; dose-response relationship |
| Document type |
D - Periodical articles |
| Country / State or Province | USA |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
Occupational medicine, epidemiology
|
| Browse category(ies) |
Animal hazards
|
