ILO Home
Go to the home page
Site map | Contact us Franšais | Espa˝ol

CISDOC database

Document ID (ISN)59043
CIS number 92-1988
ISSN - Serial title 0748-2337 - Toxicology and Industrial Health
Year 1991
Convention or series no.
Author(s) Mehlman M.A., Legator M.S.
Title Dangerous and cancer-causing properties of products and chemicals in the oil refining and petrochemical industry - Part II. Carcinogenicity, mutagenicity, and developmental toxicity of 1,3-butadiene
Bibliographic information 1991, Vol.7, No.3, p.207-220. Illus. 29 ref.
Abstract 1,3-butadiene (BD) is present in synthetic rubber and motor fuels (gasoline). BD is shown to cause lymphocytic lymphomas, heart haemangiosarcomas, lung alveolar bronchiolar cancers, forestomach-squamous cell cancers, harderian gland neoplasms, preputial gland adenoma or carcinoma, liver-hepatocellular cancers, mammary gland acinar cell carcinomas, ovary-glanulosa cell carcinoma, brain cancers, pancreas adenoma and carcinoma, testis-Leydig cell tumours, thyroid follicular adenoma and carcinoma, and zymbal gland carcinoma in rodents and to date no exposure level has been established at which this chemical does not cause cancers. In humans BD causes increase in lymphomas, leukaemias, and other cancers of haematopoietic systems and organs. BD is also a potent alkylating agent, directly toxic to developing embryos and damages progeny after parental exposure. For previous article, see CIS 92-206.
Descriptors (primary) toxic effects; carcinogens; butadiene; neoplasms; genetic effects; petrochemical industry; toxicity evaluation
Descriptors (secondary) mutagenic effects; embryotoxic effects; alkylating substances; leukaemia; petroleum refining; lymphoma; mortality; animal experiments; rodents
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Chemicals, plastics and rubber
Broad subject area(s) Chemical safety
Browse category(ies) Antifertility and prenatal effects
Genetic factors in reaction to exposures
Aliphatic and alicyclic hydrocarbons
Petrochemical industry
Butadiene
Chemical industry