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CISDOC database

Document ID (ISN)58807
CIS number 92-1533
ISSN - Serial title 0007-1072 - British Journal of Industrial Medicine
Year 1991
Convention or series no.
Author(s) Finotto S., Fabbri L.M., Rado V., Mapp C.E., Maestrelli P.
Title Increase in numbers of CD8 positive lymphocytes and eosinophils in peripheral blood of subjects with late asthmatic reactions induced by toluene diisocyanate
Bibliographic information Feb. 1991, Vol.48, No.2, p.116-121. Illus. 24 ref.
Abstract Occupational asthma induced by toluene diisocyanate (TDI, tolylene diisocyanate) shares several features with allergic asthma, but the mechanism of action of TDI is poorly understood. Ten sensitised subjects, previously shown to develop a dual or late asthmatic reaction after inhaling TDI, were examined. In each subject, forced expiratory volume in one second was measured and venous blood was taken before, and at intervals after exposure to TDI. Filtered air was used as a control. Differential leucocyte counts were determined and phenotypic analysis was performed by immunofluorescence on mononuclear cells using monoclonal antibodies. Five subjects developed a dual asthmatic reaction and 5 had a late reaction. Percentage of CD8-positive lymphocytes increased 8h after exposure to TDI in the subjects with an isolated late reaction. The events triggered by exposure to TDI in sensitised subjects included changes in lung function and systemic effects which lasted longer than bronchoconstriction and concerned suppressor/cytotoxic lymphocytes and eosinophils; TDI-induced late asthmatic reactions may be associated with an immunological response to TDI or its products.
Descriptors (primary) tolylene diisocyanate; serological reactions; allergic asthma
Descriptors (secondary) blood count; 2,4-tolylene diisocyanate; functional respiratory disorders; sensitization; immunology; inhalation tests; human experiments
Document type D - Periodical articles
Country / State or ProvinceItaly
Subject(s) Toxic and dangerous substances
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Isocyanates
Cyano compounds
Allergies