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Document ID (ISN)58758
CIS number 92-1623
ISSN - Serial title 0002-9262 - American Journal of Epidemiology
Year 1991
Convention or series no.
Author(s) Jńrup L., Pershagen G.
Title Arsenic exposure, smoking, and lung cancer in smelter workers - A case-control study
Bibliographic information 15 Sep. 1991, Vol.134, No.6, p.545-551. 31 ref.
Abstract A cohort of 3,916 Swedish copper smelter workers employed for at least 3 months between 1928 and 1967 was followed up through 1981. Arsenic exposure was estimated for different time periods at each workplace within the smelter. Detailed job records were linked to the exposure matrix, thus forming individual cumulative arsenic exposure measures for each smelter worker. Smoking history was collected for 107 lung cancer cases and 214 controls from the cohort. Lung cancer risks were positively related to cumulative arsenic exposure with smoking-standardised relative risks ranging from 0.7-8.7 in different exposure groups. A negative confounding by smoking was suggested in the higher exposure categories. The interaction between arsenic and smoking for the risk of developing lung cancer was intermediate between additive and multiplicative and appeared less pronounced among heavy smokers.
Descriptors (primary) Sweden; arsenic; smelting plants; lung cancer; smoking
Descriptors (secondary) epidemiologic study; statistical evaluation; dose-response relationship
Document type D - Periodical articles
Country / State or ProvinceSweden
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Smelting and refining operations
Arsenic and compounds
Inorganic substances