| Document ID (ISN) | 58672 |
| CIS number |
92-1654 |
| ISBN(s) |
91-7045-139-7 |
| Year |
1991 |
| Convention or series no. |
Arbete och hälsa 1991:37
|
| Author(s) |
Knudsen L.E. |
| Title |
Nordic Expert Group for Documentation of Occupational Exposure Limits - 97. Dimethyl sulfoxide |
| Original title |
Nordiska expertgruppen för gränsvärdesdokumentation - 97. Dimethylsulfoxid [in Danish] |
| Bibliographic information |
Arbetsmiljöinstitutet, Förlagstjänst, 171 84 Solna, Sweden, 1991. 36p. 113 ref. |
| Abstract |
The literature on dimethyl sulfoxide was reviewed and evaluated. DMSO has a very low acute toxicity, and chronic effects are seen only at high exposure levels. The critical toxicological effects are irritation (skin and mucous membranes), central nervous system effects (dizziness and nausea) and disturbance of normal cellular functions, which contribute to development of cancer and teratogenic effects. Occupational exposure is most likely to occur by skin contact; DMSO also greatly enhances the permeability of the skin to other substances. Further studies on the genotoxic, teratogenic and carcinogenic effects of DMSO are necessary before these hazards can be properly evaluated. |
| Descriptors (primary) |
irritants; Nordic Countries; carcinogenic effects; teratogenic effects; neurological effects; dimethyl sulfoxide |
| Descriptors (secondary) |
literature survey; criteria document; determination of exposure limits |
| Document type |
E - Books, reports, proceedings |
| Country / State or Province | Denmark |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Organosulfur compounds
Genetic factors in reaction to exposures
Antifertility and prenatal effects
Diseases of the nervous system
|
