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CISDOC database

Document ID (ISN)58209
CIS number 92-960
Year 1988
Convention or series no. EUR 11478 EN
Author(s)
Commission of the European Communities
Title Biological indicators for the assessment of human exposure to industrial chemicals: Aromatic amines, aromatic nitro compounds, carbamate pesticides, nickel
Bibliographic information Office for Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg, 1988. 80p. Illus. Bibl.ref.
Abstract The available data on the human health effects, metabolism and biological indicators of these substances are reviewed. Conclusions reached: for aromatic amines and aromatic nitro compounds, determination of methaemoglobin level is used for detecting recent exposure to those compounds capable of oxidising haemoglobin iron, along with measurement of the compounds or their metabolites in urine; the internal dose and level of exposure to carbamates can be assessed by determination of their urinary metabolites; for carbamate insecticides with anticholinesterase activity, blood cholinesterases can be used as bioindicators of absorption and effect; determination in plasma/serum and urine are the most useful methods for biological monitoring of nickel exposure.
Descriptors (primary) agricultural chemicals; nickel and compounds; European Communities; aromatic amines; aromatic nitro compounds; pesticides; exposure evaluation; exposure tests; carbamates
Descriptors (secondary) cholinesterase monitoring; determination in urine; literature survey; nickel; metabolic process; carbofuran; chlorpropham; benomyl; aldicarb; health hazards; biological threshold limits; biological effects; determination in biological matter; haemoglobin monitoring; carbaryl; toxic effects
Document type E - Books, reports, proceedings
Country / State or ProvinceEuropean Union
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Biological monitoring
Exposure evaluation
Agricultural chemicals
Aliphatic nitro compounds
Nickel and compounds
Amides
Aromatic amines
Inorganic substances