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Document ID (ISN)58165
CIS number 92-935
ISSN - Serial title 0003-9896 - Archives of Environmental Health
Year 1989
Convention or series no.
Author(s) Soskolne C.L., Pagano G., Cippolaro M., Beaumont J.J., Giordano G.G.
Title Epidemiologic and toxicologic evidence for chronic health effects and the underlying biologic mechanisms involved in sub-lethal exposures to acidic pollutants
Bibliographic information May-June 1989, Vol.44, No.3, p.180-191. 160 ref.
Abstract Since the 1880s, an extensive literature has evolved examining the biological effects of acidification on cells. More recently, effects on the health of human and other species of acidic agents contained, for example, in pollutants have been suggested, particularly relating to long-term exposures. This paper provides a review of the epidemiological and toxicological evidence concerning health effects - particularly carcinogenicity - attributable to acid exposure. Underlying biological mechanisms that explain adverse health outcomes include pH modulation of toxicity for a number of xenobiotics (including carcinogens, genotoxins, and teratogens), and low-pH-induced changes of cells involving, for example, alterations in mitotic and enzyme regulation. More focused research is recommended to test the relationship between long-term exposures to acidic agents (with a consequent lowered cellular pH) and various health effects.
Descriptors (primary) toxic effects; biological effects; environmental pollution; acids
Descriptors (secondary) literature survey
Document type D - Periodical articles
Country / State or ProvinceCanada; Italy; USA
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Inorganic acids
Environmental pollution