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CISDOC database
| Document ID (ISN) | 58165 |
| CIS number |
92-935 |
| ISSN - Serial title |
0003-9896 - Archives of Environmental Health |
| Year |
1989 |
| Convention or series no. |
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| Author(s) |
Soskolne C.L., Pagano G., Cippolaro M., Beaumont J.J., Giordano G.G. |
| Title |
Epidemiologic and toxicologic evidence for chronic health effects and the underlying biologic mechanisms involved in sub-lethal exposures to acidic pollutants |
| Bibliographic information |
May-June 1989, Vol.44, No.3, p.180-191. 160 ref. |
| Abstract |
Since the 1880s, an extensive literature has evolved examining the biological effects of acidification on cells. More recently, effects on the health of human and other species of acidic agents contained, for example, in pollutants have been suggested, particularly relating to long-term exposures. This paper provides a review of the epidemiological and toxicological evidence concerning health effects - particularly carcinogenicity - attributable to acid exposure. Underlying biological mechanisms that explain adverse health outcomes include pH modulation of toxicity for a number of xenobiotics (including carcinogens, genotoxins, and teratogens), and low-pH-induced changes of cells involving, for example, alterations in mitotic and enzyme regulation. More focused research is recommended to test the relationship between long-term exposures to acidic agents (with a consequent lowered cellular pH) and various health effects. |
| Descriptors (primary) |
toxic effects; biological effects; environmental pollution; acids |
| Descriptors (secondary) |
literature survey |
| Document type |
D - Periodical articles |
| Country / State or Province | Canada; Italy; USA |
| Subject(s) |
Occupational pathology
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| Broad subject area(s) |
Chemical safety
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| Browse category(ies) |
Environmental pollution
Inorganic acids
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