|Document ID (ISN)||57763|
|ISSN - Serial title
||0003-0805 - American Review of Respiratory Disease
|Convention or series no.
||Hessel P.A., Sluis-Cremer G.K., Lee S.L.
||Distribution of silicotic collagenization in relation to smoking habits
||Aug. 1991, Vol.144, No.2, p. 297-301. 23 ref.
||A causal association between smoking and silicosis would seriously confound the association between silicosis and lung cancer. The analysis presented here assesses this association using data on deceased gold miners. There was a slight inverse relationship between smoking and silicotic collagenisation of the parenchyma and a stronger negative relationship between smoking and silicotic collagenisation of the pleura. No association between silicotic collagenisation of the hilar glands and smoking was detected. The data suggest that the lack of smoking histories in studies of the association between silicosis and lung cancer probably does not seriously confound risk estimates. The distribution of silicotic collagenisation in the lungs of smokers and non-smokers is consistent with enhanced mucous interception, more central deposition in the lungs, and proportionally more lymphatic clearance to the hilum (as opposed to the pleura) of silica particles in smokers compared to non-smokers.
||mineral dust; free silica; risk factors; lung cancer; silicosis; smoking
||South Africa; silica; gold mining; autopsy; synergism; lung deposition
||D - Periodical articles
|Country / State or Province||Canada; South Africa|
|Broad subject area(s)
||Occupational medicine, epidemiology
||Diseases of the respiratory system (except for pneumoconiosis & similar)