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CISDOC database

Document ID (ISN)57763
CIS number 92-462
ISSN - Serial title 0003-0805 - American Review of Respiratory Disease
Year 1991
Convention or series no.
Author(s) Hessel P.A., Sluis-Cremer G.K., Lee S.L.
Title Distribution of silicotic collagenization in relation to smoking habits
Bibliographic information Aug. 1991, Vol.144, No.2, p. 297-301. 23 ref.
Abstract A causal association between smoking and silicosis would seriously confound the association between silicosis and lung cancer. The analysis presented here assesses this association using data on deceased gold miners. There was a slight inverse relationship between smoking and silicotic collagenisation of the parenchyma and a stronger negative relationship between smoking and silicotic collagenisation of the pleura. No association between silicotic collagenisation of the hilar glands and smoking was detected. The data suggest that the lack of smoking histories in studies of the association between silicosis and lung cancer probably does not seriously confound risk estimates. The distribution of silicotic collagenisation in the lungs of smokers and non-smokers is consistent with enhanced mucous interception, more central deposition in the lungs, and proportionally more lymphatic clearance to the hilum (as opposed to the pleura) of silica particles in smokers compared to non-smokers.
Descriptors (primary) mineral dust; free silica; risk factors; lung cancer; silicosis; smoking
Descriptors (secondary) South Africa; silica; gold mining; autopsy; synergism; lung deposition
Document type D - Periodical articles
Country / State or ProvinceCanada; South Africa
Subject(s) Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Smoking
Pneumoconioses