|Document ID (ISN)||57740|
|ISSN - Serial title
||0300-5771 - International Journal of Epidemiology
|Convention or series no.
||Graves A.B., Van Duijn C.M., Chandra V., Fratiglioni L., Heyman A., Jorm A.F., Kokmen E., Kondo K., Mortimer J.A., Rocca W.A., Shalat S.L., Soininen H., Hofman A.
||Occupational exposures to solvents and lead as risk factors for Alzheimer's disease: A collaborative re-analysis of case-control studies
||1991, Vol.20, no.2 (suppl.2), p.S58-S61. 20 ref.
||A meta-analysis, involving the secondary analysis of original data from 11 case-control studies of Alzheimer's disease, is presented for occupational exposures to solvents and lead. Three studies included data on occupational exposure to solvents. The meta-analysis was particularly useful in validating negative results from individual studies and in increasing the statistical power for the analysis of lead exposure, where stratum-specific cell sizes were frequently smaller than 5 in individual studies. However, since exposure in the various studies was ascertained in a rather broad manner, prospective studies are recommended which focus on high-risk occupational populations and which determine the incidence of Alzheimer's disease in these and comparable unexposed populations.
||lead; solvents; diseases of central nervous system
||epidemiologic study; statistical evaluation; risk factors
||D - Periodical articles
|Country / State or Province||Netherlands; USA|
||Toxic and dangerous substances
|Broad subject area(s)
||Diseases of the nervous system
Lead and compounds