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CISDOC database

Document ID (ISN)57740
CIS number 92-533
ISSN - Serial title 0300-5771 - International Journal of Epidemiology
Year 1991
Convention or series no.
Author(s) Graves A.B., Van Duijn C.M., Chandra V., Fratiglioni L., Heyman A., Jorm A.F., Kokmen E., Kondo K., Mortimer J.A., Rocca W.A., Shalat S.L., Soininen H., Hofman A.
Title Occupational exposures to solvents and lead as risk factors for Alzheimer's disease: A collaborative re-analysis of case-control studies
Bibliographic information 1991, Vol.20, no.2 (suppl.2), p.S58-S61. 20 ref.
Abstract A meta-analysis, involving the secondary analysis of original data from 11 case-control studies of Alzheimer's disease, is presented for occupational exposures to solvents and lead. Three studies included data on occupational exposure to solvents. The meta-analysis was particularly useful in validating negative results from individual studies and in increasing the statistical power for the analysis of lead exposure, where stratum-specific cell sizes were frequently smaller than 5 in individual studies. However, since exposure in the various studies was ascertained in a rather broad manner, prospective studies are recommended which focus on high-risk occupational populations and which determine the incidence of Alzheimer's disease in these and comparable unexposed populations.
Descriptors (primary) lead; solvents; diseases of central nervous system
Descriptors (secondary) epidemiologic study; statistical evaluation; risk factors
Document type D - Periodical articles
Country / State or ProvinceNetherlands; USA
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the nervous system
Lead and compounds
Inorganic substances