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Document ID (ISN)57443
CIS number 92-241
Year 1991
Convention or series no. DSHH (NIOSH) Publication No.91-112
Title NIOSH Current Intelligence Bulletin No.55 - Carcinogenicity of acetaldehyde and malonaldehyde, and mutagenicity of related low-molecular-weight aldehydes
Bibliographic information National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA, Sep. 1991. 39p. Illus. 192 ref.
Abstract This bulletin presents recent information about the potential carcinogenicity and mutagenicity of acetaldehyde and malonaldehyde and discusses the chemical reactivity and mutagenicity of 9 related aldehydes (acrolein, butyraldehyde, crotonaldehyde, glutaraldehyde, glyoxal, paraformaldehyde, propiolaldehyde, propionaldehyde and valeraldehyde). Results of animal expirements provide sufficent evidence to conclude that acetaldehyde and malonaldehyde are carcinogenic in laboratory animals. Evidence for the carcinogenicity of the other 9 aldehydes is inconclusive. Adequate epidemiologic data are not available from workers exposed to acetaldehyde or malonaldehyde, although both chemicals meet the OSHA criteria for potential carcinogens and it is recommended that worker exposure be reduced to the lowest feasible concentration.
Descriptors (primary) mutagenic effects; acetaldehyde; carcinogenic effects; toxicology; malonaldehyde
Descriptors (secondary) literature survey; glutaraldehyde; 2-propynal; pentanal; crotonaldehyde; butyraldehyde; criteria document; malonaldehyde, sodium salt; propionaldehyde; paraformaldehyde; limitation of exposure; acrolein; glyoxal
Document type E - Books, reports, proceedings
Country / State or ProvinceUSA
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Antifertility and prenatal effects
Aldehydes
Genetic factors in reaction to exposures