| Document ID (ISN) | 57406 |
| CIS number |
92-318 |
| ISSN - Serial title |
0098-7484 - Journal of the American Medical Association |
| Year |
1991 |
| Convention or series no. |
|
| Author(s) |
Nagafuchi S., Kashiwagi S., Okada K., Anzai K., Nakamura M., Nishimura Y., Sasazuki T., Niho Y. |
| Title |
Reversal of non-responders and post-exposure prophylaxis by intradermal hepatitis B vaccination in Japanese medical personnel |
| Bibliographic information |
22/29 May 1991, Vol.265, No.20, p.2679-2683. Illus. 37 ref. |
| Abstract |
Thirty-one Japanese non-responders to subcutaneous hepatitis B vaccination and 15 medical personnel who were accidentally exposed to specimens positive for hepatitis B e antigen and were given hepatitis B immunoglobin were intradermally immunised with hepatitis B vaccine every 2 weeks until delayed type hypersensitivity skin reaction to hepatitis B surface antigen (HBsAg) became positive. One year later, 74% of the non-responders still had sufficiently high levels of anti-HBsAg, while for the exposed personnel protection was 100%. Intradermal hepatitis B vaccination is therefore seen to be useful in reversing non-responsiveness to hepatitis B surface antigen and for prophylaxis after exposure. |
| Descriptors (primary) |
Japan; infection control; infectious hepatitis |
| Descriptors (secondary) |
vaccination |
| Document type |
D - Periodical articles |
| Country / State or Province | Japan |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Biological hazards
|
| Browse category(ies) |
Liver diseases
Bacterial and parasitic diseases
Viral diseases (other than aids)
|
