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Document ID (ISN)57404
CIS number 92-224
ISSN - Serial title 0140-6736 - Lancet
Year 1991
Convention or series no.
Author(s) Saracci R., Kogevinas M., Bertazzi P., Bueno de Mesquita B.H., Coggon D., Green L.M., Kauppinen T., L'Abbé K.A., Littorin M., Lynge E., Mathews J.D., Neuberger M., Osman J., Pearce N., Winkelmann R.
Title Cancer mortality in workers exposed to chlorophenoxy herbicides and chlorophenols
Bibliographic information 26 Oct. 1991, Vol.338, No.8774, p.1027-1032. 35 ref.
Abstract This paper reports a historical cohort study of mortality in an international register of 18,910 chlorophenoxy herbicide production workers or sprayers from 10 countries. Exposure was reconstructed through questionnaires, factory or spraying records and job histories. A non-significant increase, based on 4 observed deaths, was noted for soft-tissue sarcoma. Increased risks were found for some uncommon neoplasms, but results are difficult to interpret because of the small numbers. The excess of soft-tissue sarcomas among sprayers is compatible with a causal role of chlorophenoxy herbicides but the excess does not seem to be specifically associated with those herbicides probably contaminated by the toxic dioxin TCDD.
Descriptors (primary) herbicides; neoplasms; health hazards; chlorophenols
Descriptors (secondary) chloromethylphenoxyacetic acid; 2,4,6-trichlorophenol; silvex; 4-(2,4-dichlorophenoxy)butanoic acid; phenoxybutyric acid; 2,3,4,6-tetrachlorophenol; pentachlorophenol; dichlorophenoxyacetic acid; trichlorophenoxyacetic acid; tetrachlorodibenzodioxin; sarcomas; epidemiologic study; 2,4-dichlorophenol; trichlorophenol; dichlorprop
Document type D - Periodical articles
Country / State or ProvinceAustralia; Austria; Canada; Denmark; Finland; France; United Kingdom; Italy; Netherlands; New Zealand; Sweden
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Agricultural chemicals
Phenols and phenolic compounds