| Document ID (ISN) | 57394 |
| CIS number |
92-234 |
| ISSN - Serial title |
0025-7818 - Medicina del lavoro |
| Year |
1988 |
| Convention or series no. |
|
| Author(s) |
Pisati G., Baruffini A., Galli C., Riboldi L., Tomasini M. |
| Title |
Selenious acid poisoning in a galvanisation worker. Description of a clinical case |
| Original title |
Intossicazione da acido selenioso in galvanica - Descrizione di un caso clinico [in Italian] |
| Bibliographic information |
Mar.-Apr. 1988, Vol.79, No.2, p.127-135. Illus. 32 ref. |
| Abstract |
Selenium, which is an essential trace element found in many animal species and in man, is highly irritating for the skin and mucous membranes. Cases of acute intoxication have been described in man with gastrointestinal disorders and irritation of the skin and upper airways. Necrotic hepatitis and cirrhosis have also been observed in animal experiments. The paper reports the case of a galvanisation worker occupationally exposed to selenious acid, probably mainly via skin absorption, who in the space of 2 weeks developed a severe irritative dermatitis on the face and arms, accompanied by acute hepatitis with steatosis and necrosis. The skin lesions, duly treated, healed in a month, but it took over a year for the signs of cytolysis to disappear. The action of the systemic toxicity of selenium appears to be due to the fact that it interferes with essential enzymatic systems (glutathione, succinicodelydrogenase, urease, methioninadenosiltransferase), with consequent disturbance of microsomial system function and fatty acid synthesis. |
| Descriptors (primary) |
selenious acid; galvanizing; hepatic diseases; dermatitis |
| Descriptors (secondary) |
acute toxicity; enzyme disturbances; case study |
| Document type |
D - Periodical articles |
| Country / State or Province | Italy |
| Subject(s) |
Metal production and metalworking
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Inorganic substances
Skin diseases
Liver diseases
Surface treatment
|
