|Document ID (ISN)||57335|
|ISSN - Serial title
||0829-0369 - Travail et santé
|Convention or series no.
||The use of experimental data in teratogenic risk assessment: Standard testing and recent developments
||L'utilisation des données expérimentales dans l'évaluation des effets tératogènes des produits industriels. Les acquis et les développements récents [in French]|
||Summer 1991, Vol.7, No.2, p.S-11 to S-16. Illus. 41 ref.
||Developmental toxicity hazard assessment of industrial chemicals usually involves an evaluation of human studies and animal data. Epidemiological data being generally scarce, adequate assessment of human risk from experimental reproductive studies requires knowledge and familiarity with the performance of conventional teratology testing protocols and understanding of several parameters involved in embryonal or foetal toxicity. This paper examines the influence of time of exposure and route of administration in standard teratology testing with special emphasis on the influence of experimental doses. The use of high dose levels in experiments frequently induces overt maternal toxicity that causes considerable difficulties in the interpretation of concurrent embryo/foetal insult. In response to these problems, most teratologists propose to rank the teratogenic potential of xenobiotics on the basis of the A/D ratio derived from the adult toxic dose (A) and the developmental toxic dose (D). The last part of the discussion focuses on the concepts of threshold, no-observed-effect level and safety factor which form the bases of extrapolation for a safe human exposure.
||teratogens; toxicology; teratogenic effects; animal experiments; industrial products
||embryotoxic effects; threshold limit values; description of technique; expectant mothers; hazard criteria
||D - Periodical articles
|Country / State or Province||Canada|
||Toxic and dangerous substances
|Broad subject area(s)
||Genetic factors in reaction to exposures
Antifertility and prenatal effects