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CISDOC database

Document ID (ISN)57267
CIS number 92-182
ISSN - Serial title 0007-1072 - British Journal of Industrial Medicine
Year 1990
Convention or series no.
Author(s) Hnizdo E.
Title Combined effect of silica dust and tobacco smoking on mortality from chronic obstructive lung disease in gold miners
Bibliographic information Oct. 1990, Vol.47, No.10, p.656-664. Illus. 24 ref.
Abstract A sample of 2209 white South African gold miners aged 45-54 between 1968-71, who started to work in mines during 1936-43, was investigated from 1968-71 to Decembber 1986. The effect of silica dust and tobacco smoking on mortality from chronic obstructive lung disease (COLD) was assessed. The combined effect of dust exposure before 1950 and years of cigarette smoking on mortality from COLD was best estimated by the multiplicative model, indicating that the 2 exposures act synergistically. All those that died of the disease were smokers. According to the estimates of attributable risk about 5% of the deaths from COLD were from the effect of dust, 34% were from smoking, and 59% were from the combined effect of dust and smoking. In conclusion, the results indicate that workers exposed to silica dust who smoke are at higher risk of dying from COLD than smokers not exposed to silica dust, as the 2 exposures act synergistically in causing COLD.
Descriptors (primary) obstructive ventilatory impairment; silica; smoking; chronic forms; gold mining; lung diseases; respirable dust; synergism; mortality
Descriptors (secondary) South Africa; symptoms; respiratory function tests; hazard evaluation; underground work
Document type D - Periodical articles
Country / State or ProvinceSouth Africa
Subject(s) Dust, aerosols and related diseases
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Mining and quarrying