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CISDOC database

Document ID (ISN)57032
CIS number 91-1951
Year 1989
Convention or series no. ECETOC Monograph No.12
Title Alternative approaches for the assessment of reproductive toxicity (with emphasis on embryotoxicity/teratogenicity)
Bibliographic information European Chemical Industry Ecology and Toxicology Centre, Avenue Louis 250, Bte 63, 1050 Bruxelles, Belgium, Nov. 1989. 50p. 116 ref.
Abstract This monograph reviews the present status of alternative in vivo and in vitro tests developed for evaluating the effects of chemicals on reproduction, and assesses their relevance and validity. It is concluded that at present no test can totally replace the existing reproductive toxicity tests which use live animals. In many instances the alternative methods can be used to screen chemicals for further technical development or further testing, and to provide information on the reproductive toxicity of those chemicals which do not warrant full-scale testing. Application of the results from the alternative test approaches to human hazard assessment is also discussed.
Descriptors (primary) antifertility effects; toxic substances; experimental determination; animal experiments; toxicity evaluation
Descriptors (secondary) embryotoxic effects; report; teratogenic effects; in vitro experiments; extrapolation animal man
Document type E - Books, reports, proceedings
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Genetic factors in reaction to exposures
Antifertility and prenatal effects