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Document ID (ISN)56913
CIS number 91-1871
ISSN - Serial title 0096-1736 - Journal of Occupational Medicine
Year 1991
Convention or series no.
Author(s) Moscato G., Dellabianca A., Vinci G., Candura S.M., Bossi M.C.
Title Toluene diisocyanate-induced asthma: Clinical findings and bronchial responsiveness studies in 113 exposed subjects with work-related respiratory symptoms
Bibliographic information June 1991, Vol.33, No.6, p.720-725. Illus. 39 ref.
Abstract We report the clinical findings and the results of inhalation challenge with toluene diisocyanate (TDI) and methacholine in 113 subjects with a history of exposure to TDI and work-related respiratory symptoms. Only some of the subjects (40.7%) had isocyanate asthma, diagnosed by a positive TDI inhalation challenge. Most reactors had a dual (30.4%) or a late (41.3%) response. The interval between the last occupational exposure and the specific challenge was significantly shorter in reactors, and among this group the number of immediate reactions to TDI decreased progressively with an increasing interval. The reactors had a significantly higher proportion of positive responses to methacholine and a significantly lower mean PD15 FEV1 (provocative dose of methacholine which provoked a 15% decrease in forced expiratory volume in 1 second): reactors 557µg, SEM 92.3; non-reactors 1346µg, SEM 128, P < .01. Methacholine challenge could not identify subjects with isocyanate asthma.
Descriptors (primary) isocyanates; tolylene diisocyanate; bronchial diseases; exposure; respiratory diseases; respiratory function tests; dose-response relationship; allergic asthma
Descriptors (secondary) individual susceptibility; smoking
Document type D - Periodical articles
Country / State or ProvinceItaly
Subject(s) Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Cyano compounds