| Document ID (ISN) | 56898 |
| CIS number |
91-1965 |
| Year |
1991 |
| Convention or series no. |
Arbeta och hälsa 1990:32
DHHS (NIOSH) Publication No.91-103
|
| Author(s) |
Johansson G. |
| Title |
NEG and NIOSH basis for an occupational health standard: Propylene glycol ethers and their acetates |
| Bibliographic information |
National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA, 1991. 47p. 56 ref. |
| Abstract |
This document, jointly prepared by NIOSH and the Nordic Expert Group for Documentation on Occupational Exposure Limits (NEG), presents a survey of the literature on the propylene glycol ethers most commonly used in industry: propylene glycol monomethyl ether (PGME), propylene glycol monomethyl ether acetate (PGMEA) (including their beta isomers) and dipropylene glycol monomethyl ether (DPGME). All the ethers reviewed are of low acute toxicity. The main effect at high doses is depression of the central nervous system. There is limited data available on mutagenic or genotoxic effects and no carcinogenicity studies are reported. The critical effect of DPGME and of the alpha isomers of PGME and PGMEA appears to be irritation to the eyes and mucous membranes. The beta isomer of PGMEA is teratogenic in laboratory animals. |
| Descriptors (primary) |
2-methoxy-1-propanol acetate; 1-methoxy-2-propanol acetate; 1-methoxy-2-propanol; organic solvents; dipropylene glycol methyl ether; toxicology; glycol ethers |
| Descriptors (secondary) |
toxic effects; literature survey; 1-(2-methoxy-1-methylethoxy)-2-propanol; propylene glycol monomethyl ether; propylene glycol monomethyl ether acetate; criteria document; animal experiments; teratogenic effects; neurological effects; dose-response relationship; irritation |
| Document type |
F - Information notes, codes of practice, standards |
| Country / State or Province | USA |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Esters and salts
Genetic factors in reaction to exposures
Glycol ethers
|
