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Document ID (ISN)56799
CIS number 91-1656
Year 1991
Convention or series no. KEMI Report 10/91
Title Effects on reproduction of dichloromethane, n-hexane and 1,1,1-trichloroethane
Bibliographic information Swedish National Chemicals Inspectorate, P.O. Box 1384, 171 27 Solna, Sweden, 1991. 70p. Bibl.ref.
Abstract This Nordic Council of Ministers report reviews the available literature on the toxicology and reproductive hazards of dichloromethane, n-hexane and 1,1,1-trichloroethane. Overall, the data from animal experiments suggest that dichloromethane does not pose any special risk to reproductive processes; there is a lack of adequate data on human fertility, teratogenicity and postnatal functions. No human reproduction studies of n-hexane are available, although animal studies suggest that it may have a toxic effect on the male human reproductive system. There is a lack of data on the effects of trichloroethane on human reproduction; animal studies show that it is not teratogenic but may cause retarded development at high exposure levels.
Descriptors (primary) antifertility effects; Norway; toxicology; 1,1,1-trichloroethane; hexane; dichloromethane
Descriptors (secondary) mutagenic effects; toxic effects; criteria document; carcinogenic effects; literature survey
Document type F - Information notes, codes of practice, standards
Country / State or ProvinceSweden
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Antifertility and prenatal effects
Halogenated hydrocarbons
Aliphatic and alicyclic hydrocarbons
Genetic factors in reaction to exposures