|Document ID (ISN)||56799|
|Convention or series no.
||KEMI Report 10/91
||Effects on reproduction of dichloromethane, n-hexane and 1,1,1-trichloroethane
||Swedish National Chemicals Inspectorate, P.O. Box 1384, 171 27 Solna, Sweden, 1991. 70p. Bibl.ref.
||This Nordic Council of Ministers report reviews the available literature on the toxicology and reproductive hazards of dichloromethane, n-hexane and 1,1,1-trichloroethane. Overall, the data from animal experiments suggest that dichloromethane does not pose any special risk to reproductive processes; there is a lack of adequate data on human fertility, teratogenicity and postnatal functions. No human reproduction studies of n-hexane are available, although animal studies suggest that it may have a toxic effect on the male human reproductive system. There is a lack of data on the effects of trichloroethane on human reproduction; animal studies show that it is not teratogenic but may cause retarded development at high exposure levels.
||antifertility effects; Norway; toxicology; 1,1,1-trichloroethane; hexane; dichloromethane
||mutagenic effects; toxic effects; criteria document; carcinogenic effects; literature survey
||F - Information notes, codes of practice, standards
|Country / State or Province||Sweden|
||Toxic and dangerous substances
|Broad subject area(s)
||Antifertility and prenatal effects
Aliphatic and alicyclic hydrocarbons
Genetic factors in reaction to exposures