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Document ID (ISN)56789
CIS number 91-1640
ISBN(s) 0-11-885613-8
Year 1990
Convention or series no. Toxicity Review TR 24
Author(s) Payne M.P., Delic J.I., Bell G.M.
Title Ammonia; 1-Chloro-2,3-epoxypropane (Epichlorohydrin); Carcinogenicity of cadmium and its compounds
Bibliographic information HMSO Books, P.O. Box 276, London SW8 5DT, United Kingdom, 1990. 12p. + 30p. + 14p. 90 + 122 + 26 ref. Price: GBP 9.00.
Abstract Toxicity review of ammonia (NH3): main effect is concentration-dependent irritation or corrosion of mucous membranes; at concentrations above 1000ppm NH3 may be lethal in animals; chronic exposure at 100ppm or more may produce severe lesions in animals; in humans accidental exposure to high concentrations (>200ppm) may lead to severe respiratory tract, lung and eye damage and even death; at <200ppm reported effects in humans include skin, eye and upper respiratory tract irritation; no clear evidence of genotoxic, carcinogenic or embryotoxic effects. Toxicity review of 1-chloro-2,3-epoxypropane (epichlorohydrin, ECH), a colourless, volatile liquid at room temperature with a chloroform-like odour: moderate toxicity and irritation effects, with little or no evidence for genotoxic, carcinogenic or reproductive effects. Carcinogenicity review of cadmium and its compounds (update of a previous review, see CIS 84-505): though cadmium fume and aerosols can be highly toxic, there is no conclusive evidence of an association between cadmium exposure and cancer.
Descriptors (primary) cadmium and compounds; irritants; United Kingdom; cadmium; toxicology; epichlorohydrin; toxic substances; ammonia
Descriptors (secondary) toxic effects; literature survey; carcinogenicity tests; animal experiments; carcinogens
Document type E - Books, reports, proceedings
Country / State or ProvinceUnited Kingdom
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Inorganic substances
Ethers
Ethylene oxide
Cadmium and compounds