| Document ID (ISN) | 56736 |
| CIS number |
91-1598 |
| ISSN - Serial title |
0003-9896 - Archives of Environmental Health |
| Year |
1990 |
| Convention or series no. |
|
| Author(s) |
Sakai T., Araki T., Ushio K. |
| Title |
Accumulation of erythrocyte nucleotides and their pattern in lead workers |
| Bibliographic information |
Sep.-Oct. 1990, Vol.45, No.5, p.273-277. Illus. 12 ref. |
| Abstract |
Nucleotides in erythrocytes of lead-exposed subjects were analysed by high-performance liquid chromatography (HPLC). Most of the pyrimidine levels correlated well with blood lead concentrations (Pb-B) and pyrimidine 5'-nucleotidase (P5N) activity. Highly significant correlations were found between Pb-B and uridine 5'-diphosphate-glucose (UDPG), cytidine 5'-triphosphate (CTP), or CDP-choline (CDPC). The levels of these compounds were sharply elevated when P5N activity was reduced to levels less than 7µmole/h.g haemoglobin (Hb), which corresponded to a Pb-B of 60µg/100g. Therefore, concentration of these nucleotides may provide a useful index of lead poisoning. Adenosine 5'-triphosphate (ATP) concentrations were correlated negatively with Pb-B, whereas adenosine 5'-monophosphate (AMP) concentrations were correlated positively with Pb-B. These results suggest that lead affects not only pyrimidine nucleotide metabolism but also purine nucleotide metabolism (the energy production system). |
| Descriptors (primary) |
nucleotides; printing industry; lead; erythrocytes; smelting plants; lead industry; exposure tests |
| Descriptors (secondary) |
pyrimidine nucleotidase; haemoglobin monitoring; chronic poisoning |
| Document type |
D - Periodical articles |
| Country / State or Province | Japan |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Biological monitoring
Inorganic substances
Printing, photography and photocopying industry
Smelting and refining operations
Lead and compounds
|
