ILO Home
Go to the home page
Site map | Contact us Franšais | Espa˝ol

CISDOC database

Document ID (ISN)56736
CIS number 91-1598
ISSN - Serial title 0003-9896 - Archives of Environmental Health
Year 1990
Convention or series no.
Author(s) Sakai T., Araki T., Ushio K.
Title Accumulation of erythrocyte nucleotides and their pattern in lead workers
Bibliographic information Sep.-Oct. 1990, Vol.45, No.5, p.273-277. Illus. 12 ref.
Abstract Nucleotides in erythrocytes of lead-exposed subjects were analysed by high-performance liquid chromatography (HPLC). Most of the pyrimidine levels correlated well with blood lead concentrations (Pb-B) and pyrimidine 5'-nucleotidase (P5N) activity. Highly significant correlations were found between Pb-B and uridine 5'-diphosphate-glucose (UDPG), cytidine 5'-triphosphate (CTP), or CDP-choline (CDPC). The levels of these compounds were sharply elevated when P5N activity was reduced to levels less than 7Ámole/h.g haemoglobin (Hb), which corresponded to a Pb-B of 60Ág/100g. Therefore, concentration of these nucleotides may provide a useful index of lead poisoning. Adenosine 5'-triphosphate (ATP) concentrations were correlated negatively with Pb-B, whereas adenosine 5'-monophosphate (AMP) concentrations were correlated positively with Pb-B. These results suggest that lead affects not only pyrimidine nucleotide metabolism but also purine nucleotide metabolism (the energy production system).
Descriptors (primary) nucleotides; printing industry; lead; erythrocytes; smelting plants; lead industry; exposure tests
Descriptors (secondary) pyrimidine nucleotidase; haemoglobin monitoring; chronic poisoning
Document type D - Periodical articles
Country / State or ProvinceJapan
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Biological monitoring
Inorganic substances
Printing, photography and photocopying industry
Smelting and refining operations
Lead and compounds