| Document ID (ISN) | 56485 |
| CIS number |
91-1277 |
| ISBN(s) |
90-5307-071-0 |
| Year |
1991 |
| Convention or series no. |
Arbeidsinspectie RA 1/91
|
| Author(s) |
Werkgroep van Deskundigen ter vaststelling van MAC-waarden (Dutch Expert Committee for Occupational Standards) |
| Title |
Health-based recommended occupational exposure limits for tetrahydrofuran |
| Bibliographic information |
Department of Social Affairs and Employment, Directorate-General of Labour (Ministerie van Sociale Zaken en Werkgelegenheid, Directoraat-Generaal van de Arbeid), Postbus 90804, 2509 LV Den Haag, Netherlands, 1991. 35p. 58 ref. |
| Abstract |
The present document is a joint production of the Dutch Expert Committee and the Nordic Group for Documentation of Occupational Exposure Limits. The risks to human health of exposure to tetrahydrofuran (THF) are evaluated. THF is often used as a solvent in adhesives for plastics and in lacquers. The most probably route of occupational exposure is by inhalation. Some results indicate that THF is metabolised by an induceable oxidative enzyme system. THF is an irritant to mucous membranes and skin. Effects on the liver and kidneys have been found in a few cases and in animal experiments. The studies of THF teratogenicity, mutagenicity and genotoxicity are negative. The critical effect of THF seems to be irritation of mucous membranes and skin. Analysis of the data available leads to a recommended occupational exposure limit of 300mg/m3 (=100ppm) TWA-8h (H notation). Summary in Dutch. |
| Descriptors (primary) |
tetrahydrofuran; threshold limit values; biological effects; Netherlands; determination of exposure limits; Sweden |
| Descriptors (secondary) |
literature survey; criteria document; toxicity evaluation; report |
| Document type |
E - Books, reports, proceedings |
| Country / State or Province | Netherlands |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Occupational exposure limits
Heterocyclic compounds
|
