| Document ID (ISN) | 56294 |
| CIS number |
91-1205 |
| ISSN - Serial title |
0098-4108 - Journal of Toxicology and Environmental Health |
| Year |
1991 |
| Convention or series no. |
|
| Author(s) |
Leung H.W. |
| Title |
Development and utilization of physiologically based pharmacokinetic models for toxicological applications |
| Bibliographic information |
Mar. 1991, Vol.32, No.3, p.247-267. Illus. 84 ref. |
| Abstract |
Recent advances in physiologically based pharmacokinetic (PB-PK) modelling have introduced novel approaches for evaluating toxicological problems. Because PB-PK models are amenable to extrapolation of tissue dosimetry, they are increasingly being applied to chemical risk assessment. This paper reviews the development of PB-PK modelling for toxicological applications. It briefly compares and contrasts the fundamental differences between conventional compartmental analysis and PB-PK modelling. The theory and principles, data requirements and the methodologies to obtain them, and the steps to construct PB-PK models are described. A comprehensive listing of PB-PK models for environmental chemicals developed to date is provided. Salient applications of PB-PK modelling to toxicological problems are illustrated with examples. Finally, the uncertainties and limitations in PB-PK modelling are also discussed. |
| Descriptors (primary) |
toxicology; biological effects; hazard evaluation; harmful substances |
| Descriptors (secondary) |
metabolic process; limitation of exposure; physiology; mathematical models; toxicity evaluation |
| Document type |
D - Periodical articles |
| Country / State or Province | USA |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Risk evaluation
|
