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Document ID (ISN)56183
CIS number 91-1239
ISBN(s) 90-5307-083-4
Year 1990
Convention or series no. Arbeidsinspectie RA 5/90
Werkgroep van Deskundigen ter vaststelling van MAC-waarden (Dutch Expert Committee for Occupational Standards)
Title Health-based recommended occupational exposure limits for 1,3-butadiene
Bibliographic information Department of Social Affairs and Employment, Directorate-General of Labour (Ministerie van Sociale Zaken en Werkgelegenheid, Directoraat-Generaal van de Arbeid), Postbus 69, 2270 MA Voorburg, Netherlands, 1990. 43p. Illus. 57 ref.
Abstract The risks to human health of exposure to 1,3-butadiene are evaluated. Attention is given to: production, uses and occurrences; environmental and biological monitoring; occupational exposure limits in various countries; toxicokinetics; toxic effects (acute toxicity, carcinogenicity, mutagenicity, and epidemiology). Based on long-term inhalation studies in rats and mice, differences between species (rats, mice) and the epidemiological data concerning cancer incidence (especially leukaemia) a risk evaluation was performed. When the risk of 4x10-3 is taken for the occupational population, the dose level will be 47.4mg/m3. With a risk level of 10-4 or 10-6 the dose level will be 1.18 and 0.012mg/m3, respectively.
Descriptors (primary) threshold limit values; Netherlands; biological effects; determination of exposure limits; butadiene
Descriptors (secondary) mutagenic effects; literature survey; criteria document; toxicity evaluation; carcinogenic effects; report
Document type E - Books, reports, proceedings
Country / State or ProvinceNetherlands
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Butadiene
Genetic factors in reaction to exposures
Occupational exposure limits
Aliphatic and alicyclic hydrocarbons