| Document ID (ISN) | 56007 |
| CIS number |
91-914 |
| ISSN - Serial title |
0019-8366 - Industrial Health |
| Year |
1990 |
| Convention or series no. |
|
| Author(s) |
Omae K., Sakurai H., Higashi T., Muto T., Ichikawa M., Sasaki N. |
| Title |
No adverse effects of lead on renal function in lead-exposed workers |
| Bibliographic information |
1990, Vol.28, No.2, p.77-83. Illus. 25 ref. |
| Abstract |
A cross-sectional study was performed on 165 male lead-exposed workers to clarify the quantitative relationships between less severe exposure to lead and its effects on renal function in 1985. Mean and range of blood lead concentration (Pb-B) were 36.5µg/dL and 6-73µg/dL, respectively. Duration of lead exposure was 0.1 to 26.3 years. No lead-related changes were detected in serum creatinine concentration, beta-2 microglobulin in urine, creatinine clearance, beta-2 microglobulin clearance, and uric acid clearance. Twenty of the 165 workers had been exposed to lead for more than 10 years with mean duration of 21.0 years. Average concentrations of Pb-B in each individual during 1972 to 1984 were 26.1-66.6µg/dL. Renal function indices of these 20 workers were not different from those of remaining lead-exposed workers whose lead exposure duration was 10 years or less. These results suggest that long-term less severe exposure to lead up to 70µg/dL of Pb-B may not cause adverse effects on renal function. |
| Descriptors (primary) |
lead; exposure evaluation; dose-response relationship; battery and dry cell manufacture; renal function tests; long-term exposure |
| Descriptors (secondary) |
renal dysfunction; determination in blood; length of exposure |
| Document type |
D - Periodical articles |
| Country / State or Province | Japan |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Inorganic substances
Exposure evaluation
Manufacturing of electrical appliances and equipment
Lead and compounds
|
