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Document ID (ISN)55965
CIS number 91-897
ISSN - Serial title 0386-300X - Acta Medica Okayama
Year 1989
Convention or series no.
Author(s) Jitsunari F., Asakawa F., Nakajima T., Shimada J., Ogata M.
Title Determination of 3,5,6-trichloro-2-pyridinol levels in the urine of termite control workers using chlorpyrifos
Bibliographic information Oct. 1989, Vol.43, No.5, p.299-306. 15 ref.
Abstract Chlorpyrifos, an organophosphorus insecticide, has been used to control termites since regulatory measures against the use of chlordanes in Japan were taken in September 1989. An improved gas chromatographic (GC) method for the assay of 3,5,6-trichloro-2-pyridinol (TCP) in the urine was developed for the biological monitoring of exposure to chlorpyrifos. Urinary TCP was separated and determined precisely (coefficient of variation 4%) with high sensitivity (detection limit, 10ng/mL) and recovery (>90%) using a wide bore capillary column (WBC column). The accuracy and precision of the method are satisfactory. The time course of urinary excretion of TCP was followed in workers. Urinary TCP was low in the off-season and high in the busy season, and varied with the length of the working period. The TCP level showed a change reciprocal to the variations in the plasma cholinesterase activity. The urinary TCP level thus seems to reflect the extent of exposure to chlorpyrifos. The decrease in cholinesterase activity is probably due to exposure to chlorpyrifos.
Descriptors (primary) chlorpyrifos; 3,5,6-trichloro-2-pyridinol; determination in urine; exposure tests; insecticides
Descriptors (secondary)
Document type D - Periodical articles
Country / State or ProvinceJapan
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Biological monitoring
Heterocyclic compounds
Esters and salts
Agricultural chemicals