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Document ID (ISN)55957
CIS number 91-849
ISBN(s) 91-7045-055-2
Year 1990
Convention or series no. Arbete och hälsa 1990:5
Author(s) Reuterwall C.,, Aringer L., Elinder C.G., Juringe L., Rannug A., Ekdahl M., Eriksson R., Gillstedt-Hedman B., Hägg G., Levin J.O., Olsson M., Pehrsson A., Rosén G.
Title Assessment, using different biological monitoring methods, of genotoxic exposure in coke oven workers
Original title Genotoxisk exponering i koksverksarbete, bedömt med flera metoder för "biological monitoring" [in Swedish]
Bibliographic information Arbetsmiljöinstitutet, Förlagstjänst, 171 84 Solna, Sweden, 1990. 64p. Illus. 76 ref.
Abstract Evaluation of information obtained from different methods designed to monitor human exposure to mutagenic/carcinogenic agents, used for the monitoring of coke oven work. Blood samples from 44 male coke oven workers, and 48 male controls (rolling-mill workers) were examined for cytogenetic damage in lymphocytes. Further, urine thioether excretion was determined for 62 of the subjects and urinary mutagenicity for 31. Levels of thioether excretion, urine mutagenicity, and cytogenetic damage did not differ between the exposed group and the control group. Smokers, however, displayed significantly higher thioether excretion, urinary mutagenicity and sister chromatid exchange frequencies than non-smokers. The absence of biological indications of genotoxic exposure related to the coke oven work suggests that these analyses are insensitive monitoring methods under the present conditions.
Descriptors (primary) coke ovens; exposure tests; genetic effects
Descriptors (secondary) mutagenic effects; smoking; aromatic hydrocarbons; report
Document type E - Books, reports, proceedings
Country / State or ProvinceSweden
Subject(s) Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Antifertility and prenatal effects
Genetic factors in reaction to exposures
Biological monitoring