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CISDOC database
Document ID (ISN) | 55930 |
CIS number |
91-895 |
ISSN - Serial title |
0025-7818 - Medicina del lavoro |
Year |
1990 |
Convention or series no. |
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Author(s) |
Apostolli P., Brandi F., Toffoletto F., Alessio L. |
Title |
Validity of urinary tests in the study of renal effects of cadmium (considered singly or combined) |
Original title |
Validità di alcuni tests urinari, considerati singolarmente o in associazione, nello studio degli effetti renali del cadmio [in Italian] |
Bibliographic information |
Mar.-Apr. 1990, Vol.81, No.2, p.147-156. Illus. 30 ref. |
Abstract |
A number of indicators of renal effect (N-acetyl-glucosaminidase, retinol binding protein, beta-2-microglobulin, albuminuria) were measured in 42 cadmium-exposed workers divided into 3 subgroups on the basis of the results of the last 10 years' biological monitoring (<3, 3-10, >10µg/L). An increase in the first 3 indicators was observed, particularly in the 3rd subgroup. Taking the indicators singly, the marked increase in RBP and beta-2-microglobulin in the heavily exposed subjects was confirmed, along with an increasing sensitivity for NAG, while albuminuria levels were unchanged. Assessment of the "degree of association" of the altered tests demonstrated that the number and type of "association" varies between the subgroups in relation to the exposure conditions: in the 1st group there were no associations between the altered tests, whereas there were 2 duplicates in the 2nd and 2 duplicates, 2 triplicates and 3 quadruplicates in the heavily exposed group. In the study of the renal effects of cadmium, it is therefore advisable to use several indicators and assess their behaviour both singly and combined, and also analyse the altered tests on the basis of the number and type of "association". |
Descriptors (primary) |
cadmium; renal function tests |
Descriptors (secondary) |
comparative study |
Document type |
D - Periodical articles |
Country / State or Province | Italy |
Subject(s) |
Toxic and dangerous substances
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Broad subject area(s) |
Chemical safety
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Browse category(ies) |
Cadmium and compounds Inorganic substances
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