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Document ID (ISN)55930
CIS number 91-895
ISSN - Serial title 0025-7818 - Medicina del lavoro
Year 1990
Convention or series no.
Author(s) Apostolli P., Brandi F., Toffoletto F., Alessio L.
Title Validity of urinary tests in the study of renal effects of cadmium (considered singly or combined)
Original title Validità di alcuni tests urinari, considerati singolarmente o in associazione, nello studio degli effetti renali del cadmio [in Italian]
Bibliographic information Mar.-Apr. 1990, Vol.81, No.2, p.147-156. Illus. 30 ref.
Abstract A number of indicators of renal effect (N-acetyl-glucosaminidase, retinol binding protein, beta-2-microglobulin, albuminuria) were measured in 42 cadmium-exposed workers divided into 3 subgroups on the basis of the results of the last 10 years' biological monitoring (<3, 3-10, >10µg/L). An increase in the first 3 indicators was observed, particularly in the 3rd subgroup. Taking the indicators singly, the marked increase in RBP and beta-2-microglobulin in the heavily exposed subjects was confirmed, along with an increasing sensitivity for NAG, while albuminuria levels were unchanged. Assessment of the "degree of association" of the altered tests demonstrated that the number and type of "association" varies between the subgroups in relation to the exposure conditions: in the 1st group there were no associations between the altered tests, whereas there were 2 duplicates in the 2nd and 2 duplicates, 2 triplicates and 3 quadruplicates in the heavily exposed group. In the study of the renal effects of cadmium, it is therefore advisable to use several indicators and assess their behaviour both singly and combined, and also analyse the altered tests on the basis of the number and type of "association".
Descriptors (primary) cadmium; renal function tests
Descriptors (secondary) comparative study
Document type D - Periodical articles
Country / State or ProvinceItaly
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Cadmium and compounds
Inorganic substances