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CISDOC database

Document ID (ISN)55874
CIS number 91-832
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 1990
Convention or series no.
Author(s) Lindbohm M.L., Taskinen H., Sallmén M., Hemminki K.
Title Spontaneous abortions among women exposed to organic solvents
Bibliographic information 1990, Vol.17, No.4, p.449-463. Illus. Bibl.ref.
Abstract This study investigates the association between medically diagnosed spontaneous abortions and occupational exposure to organic solvents. The study population was composed of women biologically monitored for solvents. The workers were classified into exposure categories on the basis of work description and the use of solvents as reported in the questionnaires, and on biological exposure measurements. The odds ratio of spontaneous abortion for solvent exposure, adjusted for potentially confounding factors, was significantly increased (2.2, 95% confidence interval [CI] = 1.2-4.1). The increase was most consistent among workers exposed to aliphatic hydrocarbons. The odds ratio was increased also among toluene-exposed shoe workers. Thus exposure to organic solvents during pregnancy, especially to aliphatic hydrocarbons, increases the risk of spontaneous abortion.
Descriptors (primary) antifertility effects; organic solvents; aliphatic hydrocarbons; exposure evaluation; abortion
Descriptors (secondary) Finland; 1,1,1-trichloroethane; trichloroethylene; tetrachloroethylene; toluene; comparative study; xylene; questionnaire survey; expectant mothers; exposure tests; styrene
Document type D - Periodical articles
Country / State or ProvinceFinland
Subject(s) Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Diseases of the reproductive system
Antifertility and prenatal effects
Aliphatic and alicyclic hydrocarbons
Genetic factors in reaction to exposures
Exposure evaluation