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CISDOC database

Document ID (ISN)55720
CIS number 91-576
ISBN(s) 0-442-00422-2
Year 1989
Convention or series no.
Author(s) Hood R.D.
U.S. Environmental Protection Agency
Title Development toxicology: Risk assessment and the future
Bibliographic information Van Nostrand Reinhold, 115 Fifth Ave., New York, NY 10003, USA; Chapman and Hall, 11 New Fetter Lane, London EC4P 4EE, United Kingdom, Dec. 1989. 279p. Illus. Approx. 810 ref. Index. Price: GBP 32.50.
Abstract Review of efforts to estimate the risk of developmental defects and disabilities in humans due to the exposure of parents to chemicals before conception, during pregnancy or during childhood. Emphasis is on areas of needed research identified by the US Environmental Protection Agency, including paternally mediated effects, nonbehavioural functional effects, pharmacokinetic and physiological models, structure-activity relationships and mathematical modelling. Carcinogenicity, interspecies differences and methodological issues are also discussed.
Descriptors (primary) antifertility effects; USA; toxicology; neoplasms; gonadotropic effects; teratogenic effects; hazard evaluation
Descriptors (secondary) embryotoxic effects; literature survey; extrapolation animal man; prediction formulae; neuropsychic effects; carcinogenic effects; mathematical models; genetic effects
Document type E - Books, reports, proceedings
Country / State or ProvinceUSA
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Antifertility and prenatal effects
Genetic factors in reaction to exposures
Toxicology
Risk evaluation