| Document ID (ISN) | 55695 |
| CIS number |
91-547 |
| ISSN - Serial title |
0007-1072 - British Journal of Industrial Medicine |
| Year |
1990 |
| Convention or series no. |
|
| Author(s) |
Roels H.A., Lauwerys R.R., Buchet J.P., Bernard A.M., Lijnen P., Van Houte G. |
| Title |
Urinary kallikrein activity in workers exposed to cadmium, lead, or mercury vapour |
| Bibliographic information |
May 1990, Vol.47, No.5, p.331-337. 35 ref. |
| Abstract |
A significant reduction of kallikrein activity in urine (assayed by its amidolytic activity) was found in 64 normotensive workers who had been exposed to cadmium for 11 years on average and whose cadmium concentrations in urine ranged from 2.2 to 33.1µg/g creatinine. The mean (geometric) urinary kallikrein acitivity (in U/g creatinine) amounted to 0.52 in the control group (n = 193) against 0.39 in the cadmium group. A reduction of aldosterone release (aldosterone in urine) associated with an increased natriuresis was also observed. This might constitute a compensatory mechanism maintaining blood pressure in the normal range. This study indicates that cadmium can induce an irreversible toxic effect in the distal nephron. It also suggests that an excessive cadmium body burden alone may not be sufficient to induce hypertension, but in individuals whose blood pressure regulation may be impaired by other factors cadmium could stimulate the development of hypertension. This study also supports the recommendation to prevent hypertensive subjects from being exposed to cadmium. There was no indication that moderate exposure to mercury vapour was associated with a reduction of kallikrein production by the kidney. |
| Descriptors (primary) |
mercury; lead; cadmium; enzyme activity; urine monitoring; kallikrein |
| Descriptors (secondary) |
hypertension |
| Document type |
D - Periodical articles |
| Country / State or Province | Belgium |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Inorganic substances
Cadmium and compounds
Biological monitoring
Mercury and compounds
Blood diseases
Lead and compounds
|
