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Document ID (ISN)55684
CIS number 91-590
ISBN(s) 91-7045-077-3
Year 1990
Convention or series no. Arbete och hälsa 1990:26
Author(s) Savolainen K.
Title Nordic Expert Group for Documentation of Occupational Exposure Limits - 89. Thiurams and dimethyldithiocarbamates
Original title Nordiska Expertgruppen för Gränsvärdesdokumentation - 89. Tiuramer och Dimetylditiokarbamater [in Swedish]
Bibliographic information Arbetsmiljöinstitutet, Förlagstjänst, 171 84 Solna, Sweden, 1990. 35p. Illus. 183 ref.
Abstract A critical survey of the literature relevant for the discussion of an occupational exposure limit is given. Disulfiram: The critical target of the toxic effects is the thyroid gland. Ferbam: The critical effects are sensitisation and cross-sensitisation with other thiurams. Thiram: The critical effects are sensitisation and cross-sensitisation with other thiurams. Thiram may also affect spermatogenesis. Ziram: The critical effects are sensitisation and cross-sensitisation with other thiurams. The present occupational exposure limit values for thiurams and dimethyldithiocarbamates are mainly based on their sensitising properties and effects on skin. There is a need to conduct short- and long-term inhalation exposure studies to clarify dose-effect relationships between effects and exposure to thiurams and dimethyldithiocarbamates in thyroids and gonads.
Descriptors (primary) Nordic Countries; ferbam; ziram; alkyl thiocarbamates; sensitization; tetramethylthiuram disulfide; thyroid disorders; gonadotropic effects; disulfiram
Descriptors (secondary) criteria document; literature survey
Document type F - Information notes, codes of practice, standards
Country / State or ProvinceFinland
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Endocrine diseases
Amides
Genetic factors in reaction to exposures
Antifertility and prenatal effects