Document ID (ISN) | 55631 |
CIS number |
91-572 |
ISBN(s) |
92-832-1250-9 |
Year |
1990 |
Convention or series no. |
|
Author(s) |
International Agency for Research on Cancer (IARC) |
Title |
IARC Monographs on the evaluation of carcinogenic risks to humans - Pharmaceutical drugs |
Bibliographic information |
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1990. 415p. Bibl.ref. Price: CHF 65.00; USD 52.00. |
Abstract |
These monographs survey the available literature on 5 antineoplastic agents, 4 antimicrobial agents, 2 diuretics, ciclosporin (an immunosuppressant), cimetidine (used in the treatment of gastric and duodenal ulcers), paracetamol (a popular analgesic and antipyretic drug) and dantron (a laxative). Data include: chemical and physical properties; production, occurrence and analysis; biological data relevant to the evaluation of carcinogenic risk to humans; carcinogenic evaluation. Appendices provide a summary table and activity profiles for genetic and related effects. Of the drugs studies, ciclosporin and thiotepa are classified as carcinogenic to humans. |
Descriptors (primary) |
antineoplastic drugs; acetaminophen; WHO; IARC; cimetidine; 5-nitrofuraldehyde (semicarbazone); furosemide; ampicillin; chloramphenicol; Thiotepa; hazard evaluation; carcinogenic effects; drugs |
Descriptors (secondary) |
toxic effects; genetic effects; ciclosporin; prednimustine; antifertility effects; dantron; tris(2-chloroethyl)amine hydrochloride; nitrofurantoin; nitrofurantoin monohydrate; ampicillin trihydrate; ampicillin sodium salt; cyclosporine; azacitidine; nitrofurantoin sodium salt; hydrochlorothiazide; chlorozotocin; list of chemical substances; epidemiologic study; animal experiments; literature survey |
Document type |
E - Books, reports, proceedings |
Subject(s) |
Toxic and dangerous substances
|
Broad subject area(s) |
Chemical safety
|
Browse category(ies) |
Risk evaluation Amides IARC Monographs Genetic factors in reaction to exposures
|