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Document ID (ISN)55631
CIS number 91-572
ISBN(s) 92-832-1250-9
Year 1990
Convention or series no.
Author(s)
International Agency for Research on Cancer (IARC)
Title IARC Monographs on the evaluation of carcinogenic risks to humans - Pharmaceutical drugs
Bibliographic information World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1990. 415p. Bibl.ref. Price: CHF 65.00; USD 52.00.
Abstract These monographs survey the available literature on 5 antineoplastic agents, 4 antimicrobial agents, 2 diuretics, ciclosporin (an immunosuppressant), cimetidine (used in the treatment of gastric and duodenal ulcers), paracetamol (a popular analgesic and antipyretic drug) and dantron (a laxative). Data include: chemical and physical properties; production, occurrence and analysis; biological data relevant to the evaluation of carcinogenic risk to humans; carcinogenic evaluation. Appendices provide a summary table and activity profiles for genetic and related effects. Of the drugs studies, ciclosporin and thiotepa are classified as carcinogenic to humans.
Descriptors (primary) antineoplastic drugs; acetaminophen; WHO; IARC; cimetidine; 5-nitrofuraldehyde (semicarbazone); furosemide; ampicillin; chloramphenicol; Thiotepa; hazard evaluation; carcinogenic effects; drugs
Descriptors (secondary) toxic effects; genetic effects; ciclosporin; prednimustine; antifertility effects; dantron; tris(2-chloroethyl)amine hydrochloride; nitrofurantoin; nitrofurantoin monohydrate; ampicillin trihydrate; ampicillin sodium salt; cyclosporine; azacitidine; nitrofurantoin sodium salt; hydrochlorothiazide; chlorozotocin; list of chemical substances; epidemiologic study; animal experiments; literature survey
Document type E - Books, reports, proceedings
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Amides
IARC Monographs
Genetic factors in reaction to exposures
Risk evaluation