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Document ID (ISN)55603
CIS number 91-528
ISSN - Serial title 0025-7818 - Medicina del lavoro
Year 1989
Convention or series no.
Author(s) Clonfero E., Granella M., Gori G.P., Venier P., Levis A.G., Morandi P., Bartolucci G.B., Saia B.
Title Urinary excretion of mutagens and cis-platinum in nursing staff exposed to cytostatic drugs in cancer therapy departments
Original title Escrezione urinaria di mutageni e cisplatino nel personale infermieristico dei reparti di oncologia medica esposto a farmaci citostatici [in Italian]
Bibliographic information Sep.-Oct. 1989, Vol.80, No.5, p.412-419. 29 ref.
Abstract Exposure to cytostatic drugs was assessed in a group of 9 nurses employed in a hospital cancer therapy department by measuring the post-shift levels of urinary mutagens and cis-platimum. A slight but significant increase in urinarymutagenic activity compared to 11 controls was observed in the non-smokers: the mean values of mutagenic acitvity on the TA100 strain in the presence of both microsomal and deconjugating enzymes were 4,418 ▒ 1,186 and 2, 468 ▒ 1,681 respectively. Conversely, the urinary platinum concentration was below the detection limit of the analytical method (10Ág/L) in all samples. The increased urinary mutagenic activity in the exposed group can probably be attributed to the absorption of cyclophosphamide either during preparation and administration of the drug, or due to accidental contact with contaminated biological fluids, in view of the fact that the level of mutagens in urine samples from cyclophosphamide-treated patients is extremely high (up to 319,478 revertants/g creatinine in the case examined).
Descriptors (primary) mutagenic effects; nursing personnel; cytostatic drugs
Descriptors (secondary) platinum; determination in urine; cyclophosphamide
Document type D - Periodical articles
Country / State or ProvinceItaly
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Health care services
Genetic factors in reaction to exposures
Antifertility and prenatal effects