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Document ID (ISN)55347
CIS number 91-188
ISSN - Serial title 0002-8894 - American Industrial Hygiene Association Journal
Year 1990
Convention or series no.
Author(s) Paustenbach D.J.
Title Health risk assessment and the practice of industrial hygiene
Bibliographic information July 1990, Vol.51, No.7, p.339-351. Illus. 124 ref.
Abstract This paper discusses how health risk assessments have been conducted over the past 10 years and some of their shortcomings. Improved methods and their impact on how exposure limits for air contaminants should be established are also discussed. Examples are given of possible pitfalls in all areas of the assessment process, i.e. hazard identification, dose-response assessment, exposure assessment and risk characterisation. It is concluded that, in future, more enlightened approaches to interpreting animal bioassay data should improve hazard identification, and biologically based disposition and cancer models will provide better estimates of actual cancer risk. Reliance on worst-case exposure scenarios should no longer be necessary in the light of better information on specific exposure parameters and improved data handling methods.
Descriptors (primary) occupational hygiene; hazard evaluation; harmful substances
Descriptors (secondary) carcinogens; exposure evaluation; mathematical models; dose-response relationship; extrapolation animal man
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Risk evaluation