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CISDOC database

Document ID (ISN)55322
CIS number 91-224
Year 1989
Convention or series no. DHHS (NIOSH) Publication No.89-111
Title NIOSH Current Intelligence Bulletin No.51 - Carcinogenic effects of exposure to propylene oxide
Bibliographic information National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA, July 1989. 14p. 53 ref.
Abstract This document summarises results of animal studies which demonstrate that propylene oxide is a direct-acting carcinogen. Human health effects of propylene oxide exposure include corneal burns, contact dermatitis, and a reduced capacity to repair DNA lesions. Epidemiological data are not available for workers exposed to propylene oxide, but as a result of findings of cancer and other tumors in experimental animals, NIOSH recommends that propylene oxide be considered a potential occupational carcinogen. Guidelines are given for minimising worker exposure including exposure monitoring, and control measures such as product substitution, use of closed systems and ventilation, worker isolation, provision of personal protective equipment, decontamination and adequate waste disposal methods.
Descriptors (primary) USA; carcinogenic effects; propylene oxide
Descriptors (secondary) mutagenic effects; toxic effects; disposal of harmful waste; threshold limit values; protective clothing; neoplasms; permissible levels; exposure evaluation; respirators; animal experiments; health hazards; workplace monitoring
Document type E - Books, reports, proceedings
Country / State or ProvinceUSA
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Genetic factors in reaction to exposures
Ethers
Ethylene oxide